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Botulinum Toxins (Botulinum Toxin) Summary

Description: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

Also Known As: Botulinum Toxin; Botulin; Toxin, Botulinum; Toxins, Botulinum; Toxins, Clostridium botulinum Show All >>

Networked: 4684 relevant articles (777 outcomes, 692 trials/studies) for this Bio-Agent

Key Diseases for which Botulinum Toxins is Relevant

  1. Pain (Aches) : 73 outcomes 52 studies in 375 results
  2. Hyperhidrosis : 53 outcomes 30 studies in 226 results
  3. Torticollis (Wryneck) : 51 outcomes 43 studies in 286 results
  4. Dystonia (Limb Dystonia) : 45 outcomes 26 studies in 280 results
  5. Cerebral Palsy (Spastic Diplegia) : 43 outcomes 76 studies in 322 results
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Drugs Related to Botulinum Toxins

  1. onabotulinumtoxinA (Botox)
  2. abobotulinumtoxinA
  3. Nitroglycerin (Dynamite)
  4. Lidocaine (Xylocaine)
  5. Cosmetics
  6. Benign essential blepharospasm
  7. Cholinergic Antagonists (Anticholinergics)
  8. Baclofen
  9. Capsaicin (Zostrix)
  10. rimabotulinumtoxinB
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Therapies Related to Botulinum Toxins

  1. Injections
  2. Intramuscular Injections
  3. Aftercare (After-Treatment)
  4. Intradermal Injections
  5. Subcutaneous Injections
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