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Alzheimer Disease (Alzheimer's Disease) Summary

Description: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Also Known As: Alzheimer's Disease; Senile Dementia; Early Onset Alzheimer Disease; Late Onset Alzheimer Disease; Primary Senile Degenerative Dementia Show All >>

Networked: 46295 relevant articles (1703 outcomes, 5783 trials/studies) for this Disease

Key Drugs and Agents for Alzheimer Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Amyloid (Amyloid Fibrils) : 267 outcomes 887 studies in 12586 results : IBA
  2. donepezil (Aricept) : 122 outcomes 223 studies in 826 results : FDA 18 Generic
  3. Cholinesterase Inhibitors (Anticholinesterases) : 99 outcomes 115 studies in 872 results : IBA
  4. Memantine (Namenda) : 69 outcomes 138 studies in 534 results : FDA 12
  5. rivastigmine (Exelon) : 68 outcomes 115 studies in 438 results : FDA 7 Generic
  6. Galantamine (Galanthamine) : 58 outcomes 104 studies in 409 results : FDA 2 Generic
  7. Acetylcholinesterase : 45 outcomes 88 studies in 770 results : IBA
  8. Tacrine (Cognex) : 43 outcomes 74 studies in 403 results : FDA 1
  9. Amyloid beta-Peptides : 39 outcomes 124 studies in 2741 results : IBA
  10. Peptides : 38 outcomes 74 studies in 1642 results : IBA
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Diseases Related to Alzheimer Disease

  1. Dementia (Dementias)
  2. Parkinson Disease (Parkinson's Disease)
  3. Neurodegenerative Diseases (Neurodegenerative Disease)
  4. Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
  5. Stroke (Strokes)
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Key Therapies for Alzheimer Disease

Efficacy Chart >>
  1. Activities of Daily Living (ADL) : 29 outcomes 162 studies in 447 results
  2. Immunotherapy : 24 outcomes 44 studies in 265 results
  3. Therapeutics : 19 outcomes 27 studies in 356 results
  4. Estrogen Replacement Therapy : 16 outcomes 28 studies in 99 results
  5. Hormone Replacement Therapy (Therapy, Hormone Replacement) : 11 outcomes 14 studies in 58 results
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