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17-(allylamino)-17-demethoxygeldanamycin (17AAG) Summary

Description: an aminoquinone macrocyclic compound; shares the ability of geldanamycin to bind to heat shock protein 90 and GRP94; IPI-504 is the hydroquinone chloride salt which is more water soluble; structure in first source

Also Known As: 17AAG; 17-(allylamino)-17-demethoxy-geldanamycin; 17-AAG; 17-allyl-aminogeldanamycin; 17-allylamino-17-demethoxygeldanamycin Show All >>

Networked: 409 relevant articles (37 outcomes, 107 trials/studies) for this Bio-Agent

Key Diseases for which 17-(allylamino)-17-demethoxygeldanamycin is Relevant

  1. Neoplasms (Cancer) : 13 outcomes 48 studies in 217 results
  2. Breast Neoplasms (Breast Cancer) : 3 outcomes 13 studies in 43 results
  3. Glioma (Gliomas) : 3 outcomes 2 studies in 13 results
  4. Pancreatic Neoplasms (Pancreatic Cancer) : 2 outcomes 5 studies in 8 results
  5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia) : 2 outcomes 1 study in 8 results
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Drugs Related to 17-(allylamino)-17-demethoxygeldanamycin

  1. Heat-Shock Proteins (Heat-Shock Protein)
  2. geldanamycin
  3. trastuzumab (Herceptin)
  4. Phosphotransferases (Kinase)
  5. Hormones
  6. Rifabutin (Ansamycin)
  7. Paclitaxel (Taxol)
  8. Cyclin D1
  9. lapatinib (GW572016)
  10. polyglutamine
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Therapies Related to 17-(allylamino)-17-demethoxygeldanamycin

  1. Heterologous Transplantation (Xenotransplantation)
  2. Radiotherapy
  3. Drug Therapy (Chemotherapy)
  4. Castration
  5. Molecular Targeted Therapy
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