Ultrabiomicroscopic study of the effects of brimonidine, apraclonidine, latanoprost and ibopamine on the chamber angle and ciliary body.

Abstract	The authors used the Zeiss Humphrey (Mod840, 50 MHz) ultrabiomicroscope to evaluate the changes that Brimonidine, Apraclonidine, Latanoprost and Ibopamine cause in the anterior chamber and on the ciliary body of healthy subjects. The eyes of 60 volunteers, separated into 4 groups according to drug instilled, were studied and the parameters analyzed were: anterior chamber depth (ACD), pupillary diameter (PD), angle opening at 500 microns from the scleral spur (AOD500), trabecular iris angle (TIA) and iris thicknesses (ID1 and ID3). The study showed the miotic effect of Brimonidine (S) that was accompanied by an angle opening (S). Apraclonidine and Latanoprost caused no statistically significant changes in the angle or in the ciliary body. Ibopamine caused mydriasis (S). The UBM, therefore, showed itself to be useful also in the study of the mechanism of action of drugs on the angular structures and on the ciliary body.
Authors	L Lo Presti, A Morgese, M Ravot, B Brogliatti, B Boles Carenini
Journal	Acta ophthalmologica Scandinavica. Supplement (Acta Ophthalmol Scand Suppl) Issue 227 Pg. 32-4 ( 1998) ISSN: 1395-3931 [Print] Denmark
PMID	9972336 (Publication Type: Comparative Study, Journal Article)
Chemical References	Adrenergic alpha-Agonists Mydriatics Ophthalmic Solutions Prostaglandins F, Synthetic Quinoxalines Brimonidine Tartrate Latanoprost apraclonidine ibopamine Clonidine Deoxyepinephrine
Topics	Adrenergic alpha-Agonists (administration & dosage, pharmacology) Aged Anterior Chamber (diagnostic imaging, drug effects) Brimonidine Tartrate Ciliary Body (diagnostic imaging, drug effects) Clonidine (administration & dosage, analogs & derivatives, pharmacology) Deoxyepinephrine (administration & dosage, analogs & derivatives, pharmacology) Female Follow-Up Studies Humans Intraocular Pressure (drug effects) Latanoprost Male Middle Aged Mydriatics (administration & dosage, pharmacology) Ophthalmic Solutions (administration & dosage, pharmacology) Prostaglandins F, Synthetic (administration & dosage, pharmacology) Quinoxalines (administration & dosage, pharmacology) Reference Values Ultrasonography

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