Association of clinical manifestations with HLA-B alleles in Takayasu arteritis.

Abstract	HLA-DNA typing using PCR-SSOP and PCR-DCP methods was performed in 85 patients with Takayasu arteritis and 492 healthy controls who had been typed for HLA by serological method. Frequencies of HLA-B52 (B5201) and B39 (B3901 and B3902) were significantly increased in the patients. Frequency of HLA-DRB11502 was also increased but it was suggested to be a reflection of its linkage disequilibrium with B52. Association of HLA-B52 and B39 with seven clinical manifestations--pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-)-B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. On the other hand, in HLA-B39 positive TA patients, frequency of renal artery stenosis was significantly increased (vs B52(+)-B39(-), OR=12.14, P<0.001, vs B52(-)-B39(-), OR=5.21, P<0.03). These observations have suggested that HLA-B52 molecule and B39 molecule would contribute to different clinical manifestations by binding different antigenic peptides to cause inflammations. Thus HLA-B molecule may play an important role in pathogenesis or determining clinical manifestations of Takayasu arteritis.
Authors	H Kitamura, Y Kobayashi, A Kimura, F Numano
Journal	International journal of cardiology (Int J Cardiol) Vol. 66 Suppl 1 Pg. S121-6 (Oct 01 1998) ISSN: 0167-5273 [Print] Netherlands
PMID	9951811 (Publication Type: Comparative Study, Journal Article)
Chemical References	DNA Primers HLA-B Antigens HLA-B39 Antigen HLA-B52 Antigen HLA-DR Antigens HLA-DRB1 Chains DNA
Topics	Alleles DNA (analysis) DNA Primers (chemistry) Female Gene Frequency HLA-B Antigens (genetics) HLA-B39 Antigen HLA-B52 Antigen HLA-DR Antigens (genetics) HLA-DRB1 Chains Histocompatibility Testing Humans Male Polymerase Chain Reaction Takayasu Arteritis (diagnosis, genetics)

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