Serum ribonuclease in patients with lung carcinoma.

Abstract

Fifty-one previously untreated cases of lung carcinoma and 7 normal healthy controls were evaluated with respect to serum ribonuclease (S-RNase) levels. Cellular immunity was tested in 22 of these 51 cases by leukocyte migration inhibition test (MIT) using extract of culture cell line of lung carcinoma. S-RNase levels in lung carcinomas were significantly elevated. There appeared to be no difference in S-RNase levels by histological classification. More striking was high S-RNase level in disseminated versus localized cases. MIT results indicated impairment of cellular immunity in those cases of more elevated S-RNase. S-RNase may be implicated in blocking phenomenon associated with neoplastic disease.

• Authors: P C Marabella, G L Tritsch, R H Moore, H Takita
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 8 Issue 6 Pg. 501-5 ( 1976) ISSN: 0022-4790 [Print] United States
• PMID: 994511 (Publication Type: Journal Article)

Chemical References

• Ribonucleases

Topics

• Adenocarcinoma (blood, enzymology, immunology)
• Carcinoma, Bronchogenic (blood, enzymology, immunology)
• Cell Migration Inhibition
• Humans
• Leukocytes (immunology)
• Lung Neoplasms (blood, enzymology, immunology)
• Ribonucleases (blood)