Abstract |
Suspension cultures of TA3-Ha mouse mammary tumor cells were treated in vitro with a single dose of macromomycin(B) (MCR) at 1 mug/ml for 24 hours. This dose, which is cytostatic but not lethal, increased the immunogenicity of the cells. Adoptive transfer of spleen cells sensitized to MCR/TA3-Ha cells evoked an immune response against MCR-treated TA3-Ha cells but not against normal TA3-Ha cells. The therapeutic effect of MCR treatment (in this case) was, to a very small extent, due to the cytostatic action and more profoundly to the increased immunogenicity of the cells so treated.
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Authors | E Coronetti, M M Lippman |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 56
Issue 6
Pg. 1275-7
(Jun 1976)
ISSN: 0027-8874 [Print] United States |
PMID | 994226
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Antigens, Neoplasm
- Bacterial Proteins
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Topics |
- Animals
- Antibiotics, Antineoplastic
(pharmacology)
- Antibody Formation
- Antigens, Neoplasm
- Bacterial Proteins
(pharmacology)
- Cell Membrane
(immunology)
- Cells, Cultured
- Female
- Immunization, Passive
- Mammary Neoplasms, Experimental
(immunology, therapy)
- Mice
- Mice, Inbred A
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