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Increased immunogenicity of TA3-Ha cells treated with the antitumor antibiotic macromomycin (B).

Abstract
Suspension cultures of TA3-Ha mouse mammary tumor cells were treated in vitro with a single dose of macromomycin(B) (MCR) at 1 mug/ml for 24 hours. This dose, which is cytostatic but not lethal, increased the immunogenicity of the cells. Adoptive transfer of spleen cells sensitized to MCR/TA3-Ha cells evoked an immune response against MCR-treated TA3-Ha cells but not against normal TA3-Ha cells. The therapeutic effect of MCR treatment (in this case) was, to a very small extent, due to the cytostatic action and more profoundly to the increased immunogenicity of the cells so treated.
AuthorsE Coronetti, M M Lippman
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 56 Issue 6 Pg. 1275-7 (Jun 1976) ISSN: 0027-8874 [Print] United States
PMID994226 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Antigens, Neoplasm
  • Bacterial Proteins
Topics
  • Animals
  • Antibiotics, Antineoplastic (pharmacology)
  • Antibody Formation
  • Antigens, Neoplasm
  • Bacterial Proteins (pharmacology)
  • Cell Membrane (immunology)
  • Cells, Cultured
  • Female
  • Immunization, Passive
  • Mammary Neoplasms, Experimental (immunology, therapy)
  • Mice
  • Mice, Inbred A

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