Three-month effects of candesartan cilexetil, an angiotensin II type 1 (AT1) receptor antagonist, on left ventricular mass and hemodynamics in patients with essential hypertension.

Abstract

Using cine magnetic resonance imaging (MRI) and echocardiography, we investigated the effects of candesartan cilexetil, a specific angiotensin II type 1 (AT1) receptor antagonist, on left ventricular (LV) mass and hemodynamics in patients with essential hypertension. Ten patients (four men and six women) with essential hypertension received candesartan cilexetil 2-8 mg/day orally for 8-12 weeks. After drug administration, systolic blood pressure (BP) decreased from 178.9 +/- 17.2 mmHg (mean +/- SD) to 150.2 +/- 14.3 mmHg (P < 0.0001) and diastolic BP from 101.4 +/- 6.5 mmHg to 87.8 +/- 11.9 mmHg (P = 0.0021). Both MRI and echocardiography revealed a significant decrease in LV mass index (LVMI) after candesartan cilexetil. MRI indicated that LVMI decreased from 111.3 +/- 31.3 g/m2 to 102.6 +/- 32.1 g/m2 (P = 0.0484) and echocardiography that LVMI decreased from 123.9 +/- 31.1 g/m2 to 115.8 +/- 31.4 g/m2 (P = 0.0316). Total systemic vascular resistance decreased significantly during treatment with candesartan cilexetil in both MRI and echocardiography assessment, from 1847.2 +/- 636.3 dynes.s.cm-5 to 1540.4 +/- 432.0 dynes.s.cm-5 (P = 0.0034) on MRI and from 1820.4 +/- 318.8 dynes.s.cm-5 to 1659.0 +/- 317.7 dynes.s.cm-5 (P = 0.0060) on echocardiography. These findings suggest that candesartan cilexetil 2-8 mg/day orally for 8-12 weeks is beneficial in the regression of cardiac hypertrophy in patients with essential hypertension.

• Authors: K Mitsunami, S Inoue, K Maeda, S Endoh, M Takahashi, M Okada, H Sugihara, M Kinoshita
• Journal: Cardiovascular drugs and therapy (Cardiovasc Drugs Ther) Vol. 12 Issue 5 Pg. 469-74 (Oct 1998) ISSN: 0920-3206 [Print] United States
• PMID: 9926278 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Angiotensin Receptor Antagonists
• Antihypertensive Agents
• Benzimidazoles
• Biphenyl Compounds
• Tetrazoles
• candesartan cilexetil

Topics

• Adult
• Aged
• Angiotensin Receptor Antagonists
• Antihypertensive Agents (therapeutic use)
• Benzimidazoles (therapeutic use)
• Biphenyl Compounds (therapeutic use)
• Blood Pressure (drug effects)
• Echocardiography
• Female
• Hemodynamics (drug effects)
• Humans
• Hypertension (drug therapy)
• Hypertrophy, Left Ventricular (drug therapy)
• Linear Models
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Prospective Studies
• Pulse
• Tetrazoles