Simultaneous p-tert-butylphenol-formaldehyde resin and p-tert-butylcatechol contact allergies in man and sensitizing capacities of p-tert-butylphenol and p-tert-butylcatechol in guinea pigs.

Abstract

In patients who are hypersensitive to p-tert-butylphenol-formaldehyde resin (PTBP-F-R), it is necessary, for diagnostic, therapeutic, and preventive reasons, to know the identity of the primary sensitizing substances, their sensitizing capacities, and their crossreaction patterns. The aims of this study were to investigate the presence of a simultaneous p-tert-butylcatechol (PTBC) contact allergy in individuals who were hypersensitive to PTBP-F-R, to investigate the sensitizing capacity of PTBC and p-tert-butylphenol (PTBP) in guinea pigs, and to study any crossreaction patterns. In 294 dermatitis patients tested with PTBP-F-R and PTBC, there was a statistically significant over-representation of simultaneous test reactions. Use of the guinea pig maximization test demonstrated that PTBC is a strong sensitizer giving crossreactions to PTBP. PTBP, however, failed to induce sensitization.

• Authors: E Zimerson, M Bruze, A Goossens
• Journal: Journal of occupational and environmental medicine (J Occup Environ Med) Vol. 41 Issue 1 Pg. 23-8 (Jan 1999) ISSN: 1076-2752 [Print] United States
• PMID: 9924717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Catechols
• Resins, Synthetic
• p-tert-butylphenolformaldehyde resin
• tert-butylcatechol

Topics

• Administration, Topical
• Animals
• Antioxidants (adverse effects)
• Catechols (adverse effects, immunology)
• Cross Reactions
• Dermatitis, Allergic Contact (immunology)
• Drug Hypersensitivity (immunology)
• Female
• Guinea Pigs
• Humans
• Occupational Exposure
• Resins, Synthetic (adverse effects)