Abstract |
Dantrolene is the only known effective treatment for malignant hyperthermia. However, its effects on the myopathic diaphragm remain unknown. The effects of dantrolene 10(-8) to 10(-4) mol litre-1 on diaphragm muscle strips in normal (n = 12) and myopathic hamsters (n = 13) were investigated in vitro in response to tetanic stimulation. We studied contraction under isotonic and isometric conditions. Data are presented as mean (SD) percent of baseline. Dantrolene induced a negative inotropic effect in normal and myopathic hamsters but no significant difference was observed between groups (active force at 10(-4) mol litre-1; 34 (7) vs 32 (11)%; ns). We conclude that dantrolene induced a comparable negative inotropic effect on diaphragm muscle in normal and myopathic hamsters.
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Authors | O Langeron, C Coirault, S Fratea, G Orliaguet, P Coriat, B Riou |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 81
Issue 4
Pg. 553-5
(Oct 1998)
ISSN: 0007-0912 [Print] England |
PMID | 9924231
(Publication Type: Journal Article)
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Chemical References |
- Muscle Relaxants, Central
- Dantrolene
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Topics |
- Animals
- Cricetinae
- Culture Techniques
- Dantrolene
(pharmacology)
- Diaphragm
(drug effects, physiopathology)
- Dose-Response Relationship, Drug
- Mesocricetus
- Muscle Contraction
(drug effects)
- Muscle Relaxants, Central
(pharmacology)
- Muscular Diseases
(physiopathology)
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