Abstract | PURPOSE: METHODS: All 15 patients had metastatic disease and had been previously treated with one 5-fluorouracil-based regimen in an adjuvant (six) or metastatic (nine) setting. RESULTS: None of the patients treated with CI-958 had an objective response to treatment. Median survival was 4.8 months after the start of treatment. Leukopenia was the major toxicity, but no patient experienced febrile neutropenia. An acute febrile reaction was seen after infusion in four of the first nine patients treated. This was abrogated by pretreatment with dexamethasone in the remaining patients. CONCLUSIONS:
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Authors | A F Shields, P A Philip, P M LoRusso, A M Ferris, M M Zalupski |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 43
Issue 2
Pg. 162-4
( 1999)
ISSN: 0344-5704 [Print] Germany |
PMID | 9923823
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Indazoles
- Intercalating Agents
- ledoxantrone
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Topics |
- Adenocarcinoma
(drug therapy)
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects, therapeutic use)
- Colorectal Neoplasms
(drug therapy)
- Drug Administration Schedule
- Female
- Humans
- Indazoles
(administration & dosage, adverse effects, therapeutic use)
- Intercalating Agents
(administration & dosage, adverse effects, therapeutic use)
- Leukopenia
(chemically induced)
- Male
- Middle Aged
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