Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma.

Abstract

A 67 year old male developed a therapy related myelodysplastic process culminating in acute myeloid leukemia 16 years following initial treatment for a large cell lymphoma. A second relapse of this leukemia showed 12% blasts including numerous giant blasts. The presence of giant blasts suggested the possibility of relapsed malignant lymphoma, however, flow cytometry and immunohistochemistry identified them as myeloid and chromosomal analysis revealed a near-tetraploid cell line. No evidence of lymphoma was seen. Although remission was induced with chemotherapy he subsequently relapsed with marrow and/or CNS involvement and was maintained on palliative therapy until he developed sepsis and died, 13 months following the observation of tetraploidy and 33 months following the onset of acute leukemia.

• Authors: S S Kaplan, W B Rybka, J Blom, S Shekhter-Levin
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 31 Issue 5-6 Pg. 617-23 (Nov 1998) ISSN: 1042-8194 [Print] United States
• PMID: 9922054 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Procarbazine
• Vincristine
• Cyclophosphamide
• Mercaptopurine
• Prednisone
• Methotrexate

Topics

• Acute Disease
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Blast Crisis (genetics, pathology)
• Chromosome Aberrations
• Combined Modality Therapy (adverse effects)
• Cyclophosphamide (administration & dosage, adverse effects)
• Fatal Outcome
• Humans
• Immunophenotyping
• Karyotyping
• Leukemia, Myeloid (etiology, genetics)
• Leukemia, Radiation-Induced (genetics, pathology)
• Lymphoma, Large B-Cell, Diffuse (drug therapy, pathology, radiotherapy)
• Male
• Mercaptopurine (administration & dosage)
• Methotrexate (administration & dosage)
• Neoplasms, Second Primary (etiology, genetics)
• Neoplastic Stem Cells (pathology)
• Palliative Care
• Polyploidy
• Prednisone (administration & dosage, adverse effects)
• Procarbazine (administration & dosage, adverse effects)
• Recurrence
• Vincristine (administration & dosage, adverse effects)