Abstract |
Two methods of measuring body temperature were compared in common marmosets. Subcutaneous temperatures were measured remotely via previously implanted subcutaneous microchips (Plexx BV, IPTT-100) prior to measurement of rectal temperature using a conventional rectal probe. Marmosets were treated with saline or the brain penetrant, 5-HT1A/B/D receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (0.3-3 mg/kg SC), which has previously been shown to induce hypothermia in guinea pigs. Body temperature was sampled immediately before drug administration and at 30-min intervals thereafter for a period of 2.5 h. SKF-99101H dose-dependently induced hypothermia in the common marmoset and there was close agreement between rectal and subcutaneous body temperatures, with an average difference in absolute body temperature of 0.26+/-0.02 degrees C. The data show that subcutaneously implanted microchips provide a simple, reliable measure of body temperature in common marmosets which is sensitive to pharmacological intervention, minimizes handling induced stress, and is minimally invasive.
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Authors | J Cilia, D C Piper, N Upton, J J Hagan |
Journal | Journal of pharmacological and toxicological methods
(J Pharmacol Toxicol Methods)
Vol. 40
Issue 1
Pg. 21-6
(Jul 1998)
ISSN: 1056-8719 [Print] United States |
PMID | 9920530
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Indoles
- Serotonin Receptor Agonists
- SKF 99101H
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Topics |
- Animals
- Body Temperature
(drug effects, physiology)
- Callithrix
- Female
- Indoles
(pharmacology)
- Male
- Rectum
(drug effects, physiology)
- Serotonin Receptor Agonists
(pharmacology)
- Skin Temperature
(drug effects, physiology)
- Time Factors
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