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The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.

Abstract
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis was investigated in beagle dogs. BL-3459, an alpha-adrenergic receptor blocking agent, phenoxybenzamine, and a beta-adrenergic receptor blocking agent, propranolol, were compared for their ability to modify the effects of adrenaline on platelet function, arterial blood pressure and myocardial damage. Adrenaline infusion led to a dose-related myocardial damage, elevation in arterial blood pressure, elevation in screen filtration pressure (SFP) and fall in platelet count. BL-3459 inhibited the elevation in SFP and the fall in platelet count as well as limiting the extent of myocardial damage. Phenoxybenzamine significantly modified all adrenaline-induced changes except the elevation in SFP. Propranolol had little effect alone and seemed to antagonize the beneficial effects of BL-3459 when the two drugs were combined. These results suggest that while other factors may also be involved, platelet aggregation and transient hypertension are correlated with the extent of adrenaline-induced myocardial necrosis observed in this model. A potent inhibitor of platelet aggregation, BL-3459, and the alpha-adrenergic receptor blocking agent, phenoxybenzamine, appear to afford protection against the observed pathological effects.
AuthorsJ S Fleming, J O Buchanan, J P Buyniski
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 40 Issue 1 Pg. 57-62 (Nov 1976) ISSN: 0014-2999 [Print] Netherlands
PMID991929 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Imidazoles
  • Quinazolines
  • Phenoxybenzamine
  • 6-methyl-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-one hydrochloride
  • Propranolol
  • Aspirin
  • Epinephrine
Topics
  • Animals
  • Aspirin (pharmacology)
  • Blood Pressure (drug effects)
  • Disease Models, Animal
  • Dogs
  • Epinephrine (antagonists & inhibitors, toxicity)
  • Female
  • Imidazoles (pharmacology)
  • Male
  • Myocardial Infarction (chemically induced)
  • Necrosis
  • Phenoxybenzamine (pharmacology)
  • Platelet Aggregation (drug effects)
  • Propranolol (pharmacology)
  • Quinazolines (pharmacology)

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