Abstract |
Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gene nucleotide sequencing. Significant changes in minor i and t determinants in hepatocellular carcinoma patients with adr hepatitis B carriers were seen. The adr subtype with t determinant was present in 14/25 (56%) of HCC patients compared with only two of 28 (7%) in asymptomatic hepatitis B carriers (P<0.001). However, the adr subtype with i determinant was present in nine of 25 (36%) of the HCC patients and also present in 24/28 (86%) of asymptomatic carriers (P<0.001). No significant changes were seen with the adw subtypes. These results show that i and t minor determinant changes are more common with adr subtypes associated with HCC than with the adw subtype. Whether these subtle changes are pathologically relevant or only a polymorphism of hepatitis B genotypes will depend on subsequent follow-up studies.
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Authors | Y Zhao, C J Oon, G K Lim |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 13
Issue 12
Pg. 1237-40
(Dec 1998)
ISSN: 0815-9319 [Print] Australia |
PMID | 9918432
(Publication Type: Journal Article)
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Chemical References |
- DNA, Viral
- Epitopes
- Hepatitis B Surface Antigens
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Topics |
- Adult
- Aged
- Carcinoma, Hepatocellular
(virology)
- DNA, Viral
(blood)
- Epitopes
(blood, genetics, immunology)
- Hepatitis B Surface Antigens
(blood, genetics, immunology)
- Hepatitis B virus
(genetics, immunology)
- Humans
- Liver Neoplasms
(virology)
- Middle Aged
- Polymerase Chain Reaction
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