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Significance of the minor i and t determinants of hepatitis B virus in hepatocellular carcinoma.

Abstract
Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gene nucleotide sequencing. Significant changes in minor i and t determinants in hepatocellular carcinoma patients with adr hepatitis B carriers were seen. The adr subtype with t determinant was present in 14/25 (56%) of HCC patients compared with only two of 28 (7%) in asymptomatic hepatitis B carriers (P<0.001). However, the adr subtype with i determinant was present in nine of 25 (36%) of the HCC patients and also present in 24/28 (86%) of asymptomatic carriers (P<0.001). No significant changes were seen with the adw subtypes. These results show that i and t minor determinant changes are more common with adr subtypes associated with HCC than with the adw subtype. Whether these subtle changes are pathologically relevant or only a polymorphism of hepatitis B genotypes will depend on subsequent follow-up studies.
AuthorsY Zhao, C J Oon, G K Lim
JournalJournal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 13 Issue 12 Pg. 1237-40 (Dec 1998) ISSN: 0815-9319 [Print] Australia
PMID9918432 (Publication Type: Journal Article)
Chemical References
  • DNA, Viral
  • Epitopes
  • Hepatitis B Surface Antigens
Topics
  • Adult
  • Aged
  • Carcinoma, Hepatocellular (virology)
  • DNA, Viral (blood)
  • Epitopes (blood, genetics, immunology)
  • Hepatitis B Surface Antigens (blood, genetics, immunology)
  • Hepatitis B virus (genetics, immunology)
  • Humans
  • Liver Neoplasms (virology)
  • Middle Aged
  • Polymerase Chain Reaction

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