The effects of treatment with a
spironolactone derivative (
SC 14266) for 9 experimental weeks on blood pressure and plasma
renin activity (PRA) were investigated in unilaterally nephroadrenalectomized rats drinking 1% saline ("unilater
nephrectomy"), unilaterally nephroadrenalectomized and contralaterally adrenal-enucleated rats drinking 1% saline ("adrenal enucleation") and intact rats drinking tap water ("normal"). The development of
hypertension in "adrenal enucleation" rats was prevented by treatment with
SC 14266 and the
drug did not significantly affect the blood pressure in either "unilateral
nephrectomy" or "normal" rats.
SC 14266 did not influence a low level of basal PRA and the blunted response of PRA to
furosemide administration in either "unilateral
nephrectomy" or "adrenal enucleation" rats. On the other hand, PRA after
furosemide administration in "normal" rats receiving
SC 14266 was significantly higher than that in those rats treated with vehicle. The results suggest that the
mineralocorticoid(s) secreted by the enucleated adrenal has a hypertensogenic property but no effect on the suppression of
renin secretion under a high
sodium intake and the unilateral
nephrectomy.