A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities.

Abstract

WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2, a major component, and minor components A1, A4, Ax8, Ax9 and Ax13 were active against gram-positive bacteria, in particular, methicillin-resistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.

• Authors: A Kato, S Nakaya, N Kokubo, Y Aiba, Y Ohashi, H Hirata, K Fujii, K Harada
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 51 Issue 10 Pg. 929-35 (Oct 1998) ISSN: 0021-8820 [Print] England
• PMID: 9917006 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Depsipeptides
• Macrolides
• Peptides, Cyclic
• lotilibcin

Topics

• Animals
• Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
• Depsipeptides
• Fermentation
• Fungi (drug effects)
• Gram-Negative Bacteria (chemistry, classification, drug effects)
• Gram-Positive Bacteria (drug effects)
• Inhibitory Concentration 50
• Leukemia L1210 (pathology)
• Macrolides
• Magnetic Resonance Spectroscopy
• Male
• Mass Spectrometry
• Methicillin Resistance
• Mice
• Mice, Inbred ICR
• Microbial Sensitivity Tests
• Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
• Staphylococcal Infections (drug therapy)
• Staphylococcus aureus (drug effects)
• Tumor Cells, Cultured