Aminopyrine disposition: studies on breath, saliva, and urine of normal subjects and patients with liver disease.

Abstract

To investigate aminopyrine disposition, breath, saliva, and urine were collected from 25 control patients, 15 patients with hepatocellular disease, and 26 patients with hepatic neoplasm after oral administration of 2 muCi [14C]aminopyrine. The percentage 14C excreted in breath 14CO2 in 2 hr (aminopyrine breath test, ABT) correlated with the breath 14CO2 elimination rate (r = 0.92, p less than 0.01), with the aminopyrine metabolic clearance rate (MCR) (r = 0.85, p less than 0.01), and with the plasma half-life of 4-aminoantipyrine (r = -0.54, p less than 0.05). The ABT permits study of aminopyrine disposition with simplicity, accuracy, and safety.

• Authors: G W Hepner, E S Vesell
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 20 Issue 6 Pg. 654-60 (Dec 1976) ISSN: 0009-9236 [Print] United States
• PMID: 991536 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carbon Radioisotopes
• Aminopyrine
• Carbon Dioxide

Topics

• Adult
• Aged
• Aminopyrine (metabolism, urine)
• Breath Tests
• Carbon Dioxide (metabolism)
• Carbon Radioisotopes
• Half-Life
• Hepatitis, Viral, Human (metabolism)
• Humans
• Liver Cirrhosis (metabolism)
• Liver Diseases (metabolism)
• Liver Neoplasms (metabolism)
• Metabolic Clearance Rate
• Methods
• Middle Aged
• Saliva (metabolism)