Effect of the antioxidant Nicanartine on the proliferative and inflammatory response after experimental balloon angioplasty.

Abstract

BACKGROUND:

Antioxidant treatment seems to reduce the development of restenosis after percutaneous transluminal angioplasty. In this study, the effect of Nicanartine, a new antioxidant drug with both antiproliferative and lipid-lowering properties, on the proliferative and inflammatory response after balloon angioplasty was investigated in a rabbit model of restenosis.

METHODS:

To induce pre-interventional plaques in the common carotid artery of 48 New Zealand White rabbits, electrostimulation was carried out for 28 days. After a break of 7 days, balloon angioplasty was performed in 36 animals, of which 18 received Nicanartine at a dose of 120 mg/kg body weight; the other 18 served as a control group. The vessels were excised by day 7 and 28 after balloon angioplasty and examined for intimal plaque size, macrophage content and proliferative activity. Bromodeoxyuridine labeling was used to determine proliferating cells in the dilated segment; macrophages were detected using the RAM-11 antibody.

RESULTS:

In the Nicanartine-treated group, immunohistological quantification 7 days after intervention showed a statistically significant (P< 0.05) reduction of both cells undergoing DNA synthesis (1.6+/-1.4% versus 3.7+/-2.2%) and intimal macrophages (0.7+/-1.2% versus 1.3+/-0.6%). Twenty-eight days after balloon angioplasty, proliferative activity in both groups was decreased to a level comparable to the non-dilated control groups. A clear trend towards smaller plaques could be seen in the Nicanartine group (0.146+/-0.077 mm2 versus 0.255+/-0.174 mm2). Total cholesterol levels did not differ significantly between the groups.

CONCLUSION:

Under treatment with Nicanartine a clear reduction in the proliferative and inflammatory response after balloon angioplasty was observed. Antioxidant treatment, especially with compounds having antiproliferative and lipid-lowering properties, appears to be an effective secondary preventive strategy after interventional treatment in patients with coronary artery disease.

• Authors: M Wohlfrom, S Hanke, J Kamenz, R Voisard, N Heise, W Seibold, C Lenz, G Quack, P Wühlfroth, H Hanke
• Journal: Coronary artery disease (Coron Artery Dis) Vol. 9 Issue 12 Pg. 831-7 ( 1998) ISSN: 0954-6928 [Print] England
• PMID: 9894928 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Pyridines
• nicanartine

Topics

• Angioplasty, Balloon (adverse effects)
• Angioplasty, Balloon, Coronary (adverse effects)
• Animals
• Antioxidants (therapeutic use)
• Carotid Artery, Common (pathology)
• Carotid Stenosis (etiology, prevention & control, therapy)
• Coronary Disease (prevention & control, therapy)
• Electric Stimulation
• Male
• Pyridines (therapeutic use)
• Rabbits
• Random Allocation
• Recurrence
• Time Factors
• Tunica Intima (pathology)