| Abstract | UKPDS: The results of the United Kingdom Prospective Diabetes Study (UKPDS) were reported in 1998. This multi-center, prospective, randomized, intervention trial of 5102 newly-diagnosed patients with type 2 diabetes mellitus was aimed at determining whether improved blood glucose control can prevent complications and reduce associated morbidity and mortality. THE RESULTS: Improved blood glucose control was shown to reduce the number of complications, mainly by reducing the effect of microangiopathy. There was however no reduction in the number of diabetes-related deaths nor in the risk of myocardial infarction or sudden death. CONTROVERSY OVER CALCIUM ANTAGONISTS: Calcium antagonists are suspected of increasing the risk of cardiovascular disease. On the basis of published reports, the JNC VI guidelines are recommended: calcium antagonists should not be used as first line treatment in diabetics. RECENT DRUGS: Acarbose, an alpha-glucosidase inhibitor, lowers post-prandial blood glucose level. It has marketing approval for single-drug regimens in France. Miglitol, another alpha-glucosidase inhibitor, would have the same therapeutic effect. Orliatort, an gastro-intestinal lipase inhibitor, is indicated in obese patients but long-term results are lacking to evaluate effects in diabetics. |
| Authors | B Bouhanick, G Berrut, P Fressinaud, M Marre
(Affiliation: Service de Médecine B, Centre Hospitalier et Universitaire d'Angers. BeBouhanick at chu-angers.fr)
|
| Journal | Presse médicale (Paris, France : 1983)
(Presse Med)
Vol. 27
Issue 39
Pg. 2015-24
(Dec 12 1998)
ISSN: 0755-4982 FRANCE |
| Vernacular Title | Diabète de type 2: nouveautés en thérapeutique. |
| PMID | 9893692
(Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article, Randomized Controlled Trial, Review)
|
| Chemical References |
- Calcium Channel Blockers
- Enzyme Inhibitors
- Hypoglycemic Agents
- Trisaccharides
- Acarbose
|
| Topics |
- Acarbose
- Calcium Channel Blockers
(therapeutic use)
- Diabetes Mellitus
(drug therapy)
- Diabetes Mellitus, Type 2
(drug therapy)
- Enzyme Inhibitors
(therapeutic use)
- Female
- Humans
- Hypoglycemic Agents
(classification)
- Male
- Obesity
- Prospective Studies
- Trisaccharides
(therapeutic use)
|
