[Acute liver injury in rats by praseodymium nitrate (author's transl)].

Abstract

After acute intoxication with praseodymium nitrate (10 mg/kg body weight i.v.), time functions of enzyme activities of GOT, GPT, ChE, AP and of free fatty acids concentration in rat serum were analysed and the results subjected to significance and correlation analysis. Time functions of free fatty acids concentration corresponded with those of enzyme activities of GOT and GPT. In the early state of intoxication serum concentrations of palmitoleinic and oleic acid were more increased than those of stearinic acid. There seems to be an alteration in the correlations of analysed measures with regard to their temporal changes parallel to the progress of intoxication.

• Authors: H Schriewer, B Gebauer, H M Rauen
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 26 Issue 3 Pg. 399-402 ( 1976) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Die akute Leberschädigung der Ratte mit Praseodymnitrat
• PMID: 989335 (Publication Type: Journal Article)

Chemical References

• Fatty Acids, Nonesterified
• Palmitic Acids
• Stearic Acids
• Aspartate Aminotransferases
• Alanine Transaminase
• Cholinesterases
• Alkaline Phosphatase
• Praseodymium

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Chemical and Drug Induced Liver Injury (blood, etiology)
• Cholinesterases (blood)
• Fatty Acids, Nonesterified (blood)
• Male
• Palmitic Acids (blood)
• Praseodymium (poisoning)
• Rats
• Stearic Acids (blood)