Abstract | OBJECTIVE AND DESIGN: MATERIALS:
Analgesic effect was tested in ICR mice by the acetic acid-induced writhing method. Antipyretic effect was studied in Sprague-Dawley rats treated with baker's yeast. Antiinflammatory activities were tested in Wistar rats with carrageenan-induced paw edema and adjuvant-induced chronic arthritis. In vitro analyses included the capabilities to inhibit cyclooxygenase activity, and to scavenge free radicals as determined by electron paramagnetic resonance (EPR). RESULTS: CONCLUSION: In addition to the well-known effect of zedoary as a stomachic, dehydrocurdione, the major component of Curcuma zedoaria Roscoe has antiinflammatory potency related to its antioxidant effect.
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Authors | T Yoshioka, E Fujii, M Endo, K Wada, Y Tokunaga, N Shiba, H Hohsho, H Shibuya, T Muraki |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 47
Issue 12
Pg. 476-81
(Dec 1998)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 9892041
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Cyclooxygenase Inhibitors
- Sesquiterpenes
- dehydrocurdione
- Carrageenan
- Acetic Acid
- Indomethacin
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Topics |
- Acetic Acid
- Analgesics
- Analgesics, Non-Narcotic
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Arthritis, Experimental
(drug therapy)
- Carrageenan
- Cyclooxygenase Inhibitors
- Edema
(chemically induced, drug therapy)
- Fever
(drug therapy)
- Indomethacin
(therapeutic use)
- Male
- Mice
- Mice, Inbred ICR
- Pain Measurement
- Plants, Medicinal
(chemistry)
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
- Sesquiterpenes
(therapeutic use)
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