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Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.

AbstractOBJECTIVE AND DESIGN:
Dehydrocurdione, a sesquiterpene isolated from zedoary, was tested for in vivo and in vitro antiinflammatory actions.
MATERIALS:
Analgesic effect was tested in ICR mice by the acetic acid-induced writhing method. Antipyretic effect was studied in Sprague-Dawley rats treated with baker's yeast. Antiinflammatory activities were tested in Wistar rats with carrageenan-induced paw edema and adjuvant-induced chronic arthritis. In vitro analyses included the capabilities to inhibit cyclooxygenase activity, and to scavenge free radicals as determined by electron paramagnetic resonance (EPR).
RESULTS:
Oral administration of dehydrocurdione (40 to 200 mg/kg) mitigated the writhing reflex. induced by acetic acid and the fever elicited by baker's yeast. A higher dose (200 mg/kg) of dehydrocurdione was required to inhibit the carrageenan-induced paw edema. Oral administration of dehydrocurdione at 120 mg/kg/day for 12 days significantly reduced chronic adjuvant arthritis. Unlike indomethacin (IC50: 0.1 microM), dehydrocurdione showed minimal cyclooxygenase inhibition. However, dehydrocurdione (100 microM to 5 mM) significantly reduced free radical formation from hydrogen peroxide and ferrous iron determined by EPR spectrometry using 5,5'-dimethyl-1-pyrroline-N-oxide as a spin trap agent.
CONCLUSION:
In addition to the well-known effect of zedoary as a stomachic, dehydrocurdione, the major component of Curcuma zedoaria Roscoe has antiinflammatory potency related to its antioxidant effect.
AuthorsT Yoshioka, E Fujii, M Endo, K Wada, Y Tokunaga, N Shiba, H Hohsho, H Shibuya, T Muraki
JournalInflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 47 Issue 12 Pg. 476-81 (Dec 1998) ISSN: 1023-3830 [Print] Switzerland
PMID9892041 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Cyclooxygenase Inhibitors
  • Sesquiterpenes
  • dehydrocurdione
  • Carrageenan
  • Acetic Acid
  • Indomethacin
Topics
  • Acetic Acid
  • Analgesics
  • Analgesics, Non-Narcotic
  • Animals
  • Anti-Inflammatory Agents (therapeutic use)
  • Arthritis, Experimental (drug therapy)
  • Carrageenan
  • Cyclooxygenase Inhibitors
  • Edema (chemically induced, drug therapy)
  • Fever (drug therapy)
  • Indomethacin (therapeutic use)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Pain Measurement
  • Plants, Medicinal (chemistry)
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Sesquiterpenes (therapeutic use)

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