Inhibition effect of dietary inulin and oligofructose on the growth of transplantable mouse tumor.

Abstract

BACKGROUND:

The influence of 15% inulin or oligofructose incorporated in to the basal diet on the growth of transplantable mouse tumor (TLT) was investigated.

MATERIAL AND METHODS:

This dietary treatment was performed starting at day 7 before tumor transplantation and continued until the end of observation. The results were evaluated by the mortality rates in the ascitic form of tumor, or by twice weekly solid tumor measurements, with vernier caliper. Mortality rates in ascitic tumors and mean solid tumor surface in these experimental groups was compared with those of animals from control groups fed basal diet without supplementary beta (2-1) fructans.

RESULTS:

The growth of both forms of transplantable mouse tumors was significantly inhibited by the supplementation of the diet with inulin or oligofructose.

CONCLUSION:

Such a nontoxic dietary treatment appears to be easily used ad without any risk for patients, and is applicable as an adjuvant factor to classical protocols of human cancer therapy.

• Authors: H S Taper, C Lemort, M B Roberfroid
• Journal: Anticancer research (Anticancer Res) 1998 Nov-Dec Vol. 18 Issue 6A Pg. 4123-6 ISSN: 0250-7005 [Print] Greece
• PMID: 9891456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Dietary Carbohydrates
• Fructans
• Insulin

Topics

• Analysis of Variance
• Animals
• Anticarcinogenic Agents (administration & dosage, therapeutic use)
• Cell Division (drug effects)
• Chemoprevention
• Dietary Carbohydrates (administration & dosage, therapeutic use)
• Dietary Supplements
• Fructans (administration & dosage, therapeutic use)
• Humans
• Insulin (administration & dosage, therapeutic use)
• Liver Neoplasms (mortality, prevention & control)
• Male
• Mice
• Mice, Inbred Strains
• Survival Rate