Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease.

Abstract

The authors studied the effect of ligation of the femoral and saphenous veins on the evolution of lipase injection-induced subcutaneous fibrosis and inflammation in the rats' hindlimbs. The superficial muscular fascia was thickened and the number of veins was increased 3 days and 3 weeks after vein ligation; both abnormalities disappeared 6 weeks postoperatively. Vein ligation did not quantitatively affect fascial thickening or fibrosing panniculitis in hindlimbs injected with lipase 6 weeks prior to sacrifice. The results contradict the proposition that lipase-induced injury of rats' subcutaneous tissues compromised by venous stasis may lead to a persistent chronic inflammation and fibrosis of the subcutaneous-fascial complex duplicating lipodermatosclerosis in man.

• Authors: J E Naschitz, J Bejar, J Mogilner, I Misselevich, Z Steiner, S Eldar, D Yeshurun, J H Boss
• Journal: Journal of dermatological science (J Dermatol Sci) Vol. 19 Issue 1 Pg. 9-16 (Jan 1999) ISSN: 0923-1811 [Print] Netherlands
• PMID: 9890369 (Publication Type: Journal Article)

Chemical References

• Lipase

Topics

• Acute Disease
• Adipose Tissue (drug effects)
• Animals
• Disease Models, Animal
• Female
• Femoral Vein (pathology, surgery)
• Hindlimb (blood supply, pathology)
• Ligation
• Lipase (administration & dosage, adverse effects)
• Male
• Panniculitis (chemically induced, pathology, physiopathology)
• Rats
• Rats, Sprague-Dawley
• Saphenous Vein (pathology, surgery)
• Skin (drug effects, metabolism, pathology)
• Vascular Diseases (physiopathology)
• Veins (pathology, surgery)
• Venous Insufficiency (physiopathology)