Effectiveness of alpha-beta arteether in clearing Plasmodium falciparum parasitemia in central India (Madhya Pradesh).

Abstract

Forty-six patients (25 Females + 21 Males) of uncomplicated Plasmodium falciparum in districts Jabalpur and Mandla of central India (Madhya Pradesh) were administered alpha-beta arteether (an ethyl derivative of qinghaosu), intramuscularly for 3 consecutive days (150 mg once a day). The results revealed that there was rapid control of fever in all the patients without administration of any antipyretic drug. The mean parasite clearance time was 30.78 +/- 10.92 hours and recrudescence/reinfection rate was 6.7% within 28 days. Study indicates that arteether, besides being a potent and fast acting schizontocidal drug, also exhibited gametocytocidal action on P. falciparum.

• Authors: N Singh, M M Shukla, O P Asthana, V P Sharma
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 29 Issue 2 Pg. 225-7 (Jun 1998) ISSN: 0125-1562 [Print] Thailand
• PMID: 9886102 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study)

Chemical References

• Antimalarials
• Artemisinins
• Sesquiterpenes
• artemotil

Topics

• Adolescent
• Adult
• Animals
• Antimalarials (pharmacology, therapeutic use)
• Artemisinins
• Female
• Humans
• India
• Malaria, Falciparum (drug therapy, parasitology)
• Male
• Middle Aged
• Parasitemia (drug therapy, parasitology)
• Plasmodium falciparum (drug effects, isolation & purification)
• Sesquiterpenes (pharmacology, therapeutic use)