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Effective treatment of autoimmune diseases with extremely low dose cyclosporine.

AbstractThe dosage of cyclosporine administered in the treatment of autoimmune diseases has generally been comparable to those required in cases of transplantation. Here we report on the successful treatment using an extremely low dose cyclosporine (1 mg/kg/day) on four patients, involving thrombocytopenia with systemic lupus erythematosus, and interstitial pneumonitis with Sjögren's syndrome, and discuss the optimal dose of cyclosporine for autoimmune-mediated manifestations.
AuthorsM Sugiyama, I Sekigawa, Y Tokano, N Iida, H Hashimoto, S Hirose (Affiliation: Department of Medicine, Juntendo Izu-Nagaoka Hospital.)
JournalNihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Nihon Rinsho Meneki Gakkai Kaishi) Vol. 21 Issue 1 Pg. 20-8 (Feb 1998) ISSN: 0911-4300 JAPAN
PMID9884547 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Cyclosporine
Topics
  • Adult
  • Autoimmune Diseases (drug therapy)
  • Cyclosporine (administration & dosage)
  • Female
  • Humans
  • Immunosuppressive Agents (administration & dosage)
  • Lung Diseases, Interstitial (drug therapy)
  • Lupus Erythematosus, Systemic (drug therapy)
  • Male
  • Middle Aged
  • Sjogren's Syndrome (drug therapy)
  • Thrombocytopenia (drug therapy)