Early treatment of
bleeding episodes in
haemophilia patients offers advantages over later treatment, including minimizing the damage caused by the haemorrhage and reducing the amount of product needed to control it.
Self-administration at home also offers greater convenience and time and cost savings for both patient and physician. We compared the amount of recombinant
activated factor VII (
rFVIIa;
NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) used in the treatment of peripheral intramuscular haemorrhages in people with
haemophilia A and B with inhibitors and in those with acquired
haemophilia, in the compassionate use, dose-finding and US home treatment studies. We also compared the response rates in each of the 3 studies. In the compassionate use setting, in which the mean time from onset of
bleeding to initiation of treatment with
rFVIIa was 5 d, the mean number of doses given per
bleeding episode was 13.6, with 63.1% of episodes without
compartment syndrome and 73% with tense muscle/
compartment syndrome having an excellent or effective response. In the dose-finding study, average time from onset of
bleeding to treatment with
rFVIIa was 9 h. The average number of doses given was 3.55, and 72% in the high-dose arm were judged to have an excellent or effective response. In the US home treatment study in which
bleeding episodes were treated earlier (mean 1.2 h from onset of
bleeding), the mean number of doses given was 2.3, and 92% had an effective response to treatment. These findings indicate that early treatment with
rFVIIa has a greater success rate, with fewer doses being required. Home treatment results in cost savings, greater convenience, and less morbidity.