HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Kinetic and immunohistochemical characteristics of mitogen-induced cutaneous hypersensitivity in chickens selected for antibody responsiveness.

Abstract
Mitogen-induced cutaneous hypersensitivity was evaluated in chickens selected for high and low antibody responses to SRBC, and in a random bred control line. Wing web swelling responses were found after subcutaneous administration of phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM), and Escherichia coli lipopolysaccharide (LPS), respectively, in all three lines. All mitogens induced significant acute 4 h wing web swelling responses, followed by a significant (classical) late 24 h wing web swelling response. The 4 h responses were significantly lower in the L line, whereas a tendency for lower responses at 24 h in the L line was found as well. Immunohistochemical evaluation of the early and late wing web swelling responses revealed extravascular localisation of leukocytes at 24 h after sensitization with mitogens, which consisted of CD4+ cells, CD8+ cells, TCR-1+ cells, and heterophils, but no B cells, whereas the 4 h swelling response was primarily characterized by oedema. Cutaneous hypersensitivity either initiated by T-cell mitogens as well as B-cell mitogens may depend for an important part on the rapid induction of local homing of lymphocytes towards the sensitizing agent, which may be mediated by an acute local expression of molecules with chemo-attractive capacities. Interpretation of cellular immunity responses in vivo such as delayed-type hypersensitivity should therefore incorporate oedema-initiating characteristics of sensitizing agents. The relationship between the magnitude of cutaneous hypersensitivity to mitogens and selection for antibody responsiveness is discussed.
AuthorsH K Parmentier, G De Vries Reilingh, M G Nieuwland
JournalVeterinary immunology and immunopathology (Vet Immunol Immunopathol) Vol. 66 Issue 3-4 Pg. 367-76 (Dec 11 1998) ISSN: 0165-2427 [Print] Netherlands
PMID9880112 (Publication Type: Journal Article)
Chemical References
  • Lipopolysaccharides
  • Mitogens
  • Phytohemagglutinins
  • Pokeweed Mitogens
  • Concanavalin A
Topics
  • Animals
  • Antibody Formation
  • Chickens (immunology)
  • Concanavalin A (administration & dosage, immunology)
  • Dermatitis, Atopic (immunology, pathology, veterinary)
  • Immunohistochemistry
  • Injections, Subcutaneous
  • Kinetics
  • Lipopolysaccharides (administration & dosage, immunology)
  • Mitogens (administration & dosage, immunology)
  • Phytohemagglutinins (administration & dosage, immunology)
  • Pokeweed Mitogens (administration & dosage, immunology)
  • Skin (drug effects, immunology, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: