[The biochemical marker dynamics of the maternal serum in different chromosomal disorders of the fetus].

Abstract

The reasons for false-positive results of Down syndrome screening have been analysed. It has been found that the family pericentric inversions of chromosome 9 in fetus are accompanied by AFP and HCG changes equal to Down syndrome pregnancies. The average marker's levels in cases of per inv (9) were: AFp-0.51 MoM, HCG-3.71 MoM. The dynamics of markers in amniotic fluid has been studied. Clinical significance of per inv (9) in medicogenetic consultation were discussed.

• Authors: S B Arbuzova, M I Nikolenko, L A Khlevnaia, O O Fedotova, V D Solov'eva, S A Malova, A V Krasnov
• Journal: TSitologiia i genetika (Tsitol Genet) 1998 Sep-Oct Vol. 32 Issue 5 Pg. 75-9 ISSN: 0564-3783 [Print] Ukraine
• Vernacular Title: Dinamika biokhimicheskikh markerov materinskoĭ syvorotochki pri razlichnykh khromosomnykh narusheniiakh u ploda.
• PMID: 9879118 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Chorionic Gonadotropin, beta Subunit, Human
• alpha-Fetoproteins

Topics

• Amniotic Fluid (chemistry)
• Biomarkers (blood)
• Chorionic Gonadotropin, beta Subunit, Human (analysis)
• Chromosome Aberrations (blood, genetics)
• Chromosome Disorders
• Chromosome Inversion
• Chromosomes, Human, Pair 9 (genetics)
• Female
• Humans
• Karyotyping
• Pregnancy
• Pregnancy Trimester, Second
• Ukraine
• alpha-Fetoproteins (analysis)