Abstract |
The hypoglycemic effect of oral insulin (20 U and 40 U) capsules coated with a pH-dependent soluble polymer ( Eudragit S100) and containing sodium salicylate (50 mg) without and with sodium cholate (50 mg) was studied in alloxan-hyperglycemic rabbits and compared with that of s.c. insulin injection (20 U). The capsules containing 20 U insulin + sodium salicylate (50 mg) produced a significant reduction in plasma glucose level to 82 and 73% of initial values at 2 and 3 hr after administration, respectively. The blood glucose level slowly returned to normal values at 5 hr. The AUC0-5 hr was 73.7 +/- 43.5 mg.hr/dl compared to 242 +/- 70.5 mg.hr/dl for insulin (20 U, s.c.) with a relative hypoglycemia of 30.4%. A higher dose of oral insulin (40 U) + sodium salicylate (50 mg) was more effective in reducing plasma glucose level which steadily decreased and reached 56% of the initial value by 5 hr (AUC0-5 hr = 132 +/- 41.5 mg.hr/dl and relative hypoglycemia = 27.3%). Sodium cholate (50 mg), however, slightly improved sodium salicylate effect producing an AUC0-5 hr of 139 +/- 37.3 mg.hr/dl with relative hypoglycemia of 28.7%. The relative hypoglycemia of pH-dependent coated capsules reached in the present experiment is the highest found so far.
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Authors | E A Hosny, N M Ghilzai, T A al-Najar, M M Elmazar |
Journal | Drug development and industrial pharmacy
(Drug Dev Ind Pharm)
Vol. 24
Issue 3
Pg. 307-11
(Mar 1998)
ISSN: 0363-9045 [Print] England |
PMID | 9876590
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Capsules
- Delayed-Action Preparations
- Excipients
- Hypoglycemic Agents
- Insulin
- Sodium Cholate
- Sodium Salicylate
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Topics |
- Animals
- Area Under Curve
- Blood Glucose
(metabolism)
- Capsules
- Delayed-Action Preparations
- Diabetes Mellitus, Experimental
(blood, drug therapy)
- Excipients
- Hydrogen-Ion Concentration
- Hypoglycemic Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Injections, Subcutaneous
- Insulin
(administration & dosage, pharmacokinetics, therapeutic use)
- Male
- Rabbits
- Sodium Cholate
- Sodium Salicylate
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