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Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells.

Abstract
Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
AuthorsS H Baek, Y O Kim, J S Kwag, K E Choi, W Y Jung, D S Han
JournalArchives of pharmacal research (Arch Pharm Res) Vol. 21 Issue 3 Pg. 353-6 (Jun 1998) ISSN: 0253-6269 [Print] Korea (South)
PMID9875457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Boranes
  • Cannabinoids
  • Nitroblue Tetrazolium
  • boron trifluoride etherate
  • Silicon Dioxide
  • cannabigerol
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Boranes
  • Cannabinoids (chemistry, isolation & purification, pharmacology)
  • Carcinoma (drug therapy)
  • Cell Survival (drug effects)
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mouth Neoplasms (drug therapy)
  • Nitroblue Tetrazolium
  • Silicon Dioxide
  • Spectrophotometry, Infrared

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