Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi.

Abstract

Several compounds, structurally related to the insect growth regulator Fenoxycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease. Some of these drugs were shown to be potent growth inhibitors of this parasite. All of these drugs had previously presented juvenoid activity on several non-related bug species such as Tenebrio molitor, Galleria mellonella, Dysdercus cingulatos, and Pyrrhocoris apterus.

• Authors: J B Rodriguez, L Zhong, R Docampo, Z Wimmer, E G Gros
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 8 Issue 22 Pg. 3257-60 (Nov 17 1998) ISSN: 0960-894X [Print] England
• PMID: 9873713 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Juvenile Hormones
• Trypanocidal Agents
• Ketoconazole

Topics

• Animals
• Juvenile Hormones (pharmacology)
• Ketoconazole (pharmacology)
• Structure-Activity Relationship
• Trypanocidal Agents (pharmacology)
• Trypanosoma cruzi (drug effects, growth & development)