The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice.

Abstract

Based on the findings that cholest-4-en-3-one, an intestinal metabolite of cholesterol, has an anti-obesity effect on animals, the structure-effect relationship of its 3-oxo derivatives and related compounds were investigated. Cholesten-3-ones, which possesses an enone structure with a carbonyl group at C3, markedly inhibit body weight gain and body fat accumulation, as well as the levels of serum triglyceride and cholesterol in animals without any clinical abnormalities.

• Authors: K Suzuki, T Shimizu, T Nakata
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 8 Issue 16 Pg. 2133-8 (Aug 18 1998) ISSN: 0960-894X [Print] England
• PMID: 9873500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholestenones
• Lipids
• cholest-4-en-3-one
• Cholesterol

Topics

• Adipose Tissue (anatomy & histology, drug effects, physiology)
• Animals
• Cholestenones (chemical synthesis, chemistry, pharmacology)
• Cholesterol (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
• Drug Design
• Lipids (blood)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred DBA
• Molecular Structure
• Organ Size (drug effects)
• Structure-Activity Relationship
• Weight Gain (drug effects)