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A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives.

Abstract
Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication.
AuthorsR Saladino, M C Danti, E Mincione, C Crestini, A T Palamara, P Savini, S Marini, M Botta
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 8 Issue 14 Pg. 1833-8 (Jul 21 1998) ISSN: 0960-894X [Print] England
PMID9873443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Pyrimidinones
Topics
  • Animals
  • Antiviral Agents (chemistry, pharmacology)
  • Cell Line
  • Dogs
  • Pyrimidinones (chemistry, pharmacology)
  • Respirovirus (drug effects, physiology)
  • Structure-Activity Relationship
  • Virus Replication (drug effects)

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