Abstract |
Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication.
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Authors | R Saladino, M C Danti, E Mincione, C Crestini, A T Palamara, P Savini, S Marini, M Botta |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 8
Issue 14
Pg. 1833-8
(Jul 21 1998)
ISSN: 0960-894X [Print] England |
PMID | 9873443
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Pyrimidinones
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Topics |
- Animals
- Antiviral Agents
(chemistry, pharmacology)
- Cell Line
- Dogs
- Pyrimidinones
(chemistry, pharmacology)
- Respirovirus
(drug effects, physiology)
- Structure-Activity Relationship
- Virus Replication
(drug effects)
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