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Discovery of FR115092: a novel antinephritic agent.

Abstract
A series of dapsone-related 4-aminopheynl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.
AuthorsT Ogino, K Tsuji, T Tojo, N Igari, N Seki, Y Sudo, T Manda, F Nishigaki, M Matsuo
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 8 Issue 1 Pg. 75-80 (Jan 06 1998) ISSN: 0960-894X [Print] England
PMID9871632 (Publication Type: Journal Article)
Chemical References
  • 5-(2-pyridylsulfonyl)-2-thiazolamine
  • Pyridines
  • Thiazoles
Topics
  • Anemia (chemically induced)
  • Animals
  • Disease Models, Animal
  • Male
  • Mice
  • Nephritis (drug therapy)
  • Pyridines (chemistry, therapeutic use, toxicity)
  • Thiazoles (chemistry, therapeutic use, toxicity)

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