Necrolytic migratory erythema, first symptom of a malignant glucagonoma: treatment by long-acting somatostatin and surgical resection. Report of three cases.

Abstract

We report three cases of malignant glucagonoma with necrolytic migratory erythema as the first clinical symptom. Long-acting somatostatin analogue was the first step of a multimodal therapeutic strategy which included surgical resection of the primary tumour in every case. Liver metastases which were present in two patients were treated by hepatic arterial chemoembolization and systemic chemotherapy in one case and by liver resection for cytoreduction and hepatic arterial chemoembolization in another case. Skin lesions resolved in all three patients.

• Authors: Z El Rassi, C Partensky, P J Valette, F Berger, J A Chayvialle
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 24 Issue 6 Pg. 562-7 (Dec 1998) ISSN: 0748-7983 [Print] England
• PMID: 9870735 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• Hormone Antagonists
• Somatostatin

Topics

• Aged
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Delayed-Action Preparations
• Diagnosis, Differential
• Erythema (etiology)
• Female
• Glucagonoma (complications, diagnosis, drug therapy, surgery, therapy)
• Hormone Antagonists (administration & dosage, therapeutic use)
• Humans
• Liver Neoplasms (secondary)
• Male
• Middle Aged
• Necrosis
• Pancreatectomy
• Pancreatic Neoplasms (complications, diagnosis, drug therapy, surgery, therapy)
• Paraneoplastic Syndromes (etiology)
• Somatostatin (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed
• Treatment Outcome