Abstract |
Human interferon-beta (HuIFN-beta) confers UV-refractoriness in association with increased DNA repair capacity to human cells. We examined the modulation of XPG gene expression by HuIFN-beta in UV-sensitive cells from Cockayne syndrome complementation B (CSB), xeroderma pigmentosum complementation A (XPA) and normal control cells. Northern blot analysis revealed that XPG mRNA was more extensively transcribed in CSB cells treated with HuIFN-beta than in those without HuIFN-beta treatment. XPG mRNA from XPA cells and normal control cells was not markedly transcribed by HuIFN-beta treatment compared to that from CSB cells. The findings suggested that different mechanisms of UV-refractoriness by HuIFN-beta exist between CS and XP.
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Authors | Y Suzuki, K Sugita, N Suzuki, K Kita, Y Higuchi, A Yamaura, Y Kohno |
Journal | International journal of molecular medicine
(Int J Mol Med)
Vol. 3
Issue 1
Pg. 87-9
(Jan 1999)
ISSN: 1107-3756 [Print] Greece |
PMID | 9864391
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA excision repair protein ERCC-5
- DNA-Binding Proteins
- Nuclear Proteins
- RNA, Messenger
- Transcription Factors
- RNA
- Interferon-beta
- Endonucleases
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Topics |
- Blotting, Northern
- Cell Line, Transformed
- Cockayne Syndrome
(genetics, pathology)
- DNA-Binding Proteins
(genetics)
- Endonucleases
- Humans
- Interferon-beta
(pharmacology)
- Nuclear Proteins
- RNA
(analysis, genetics)
- RNA, Messenger
(genetics)
- Transcription Factors
- Transcription, Genetic
(drug effects)
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