Abstract |
We have studied the efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, administered orally for the prevention of postoperative vomiting after tonsillectomy in children. In a randomized, double-blind, placebo-controlled study, 160 paediatric patients, ASA 1, aged 4-10 yr, received placebo or granisetron (20, 40 or 80 micrograms kg-1) (n = 40 each) orally, 1 h before surgery. A standard general anaesthetic technique was used throughout. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 40%, 48%, 85% and 90% of patients who had received placebo, or granisetron 20, 40 or 80 micrograms kg-1, respectively (P < 0.05; overall Fisher's exact probability test). There were no clinically important adverse events. We conclude that preoperative oral granisetron, in doses more than 40 micrograms kg-1, was effective for the prevention of postoperative vomiting in children.
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Authors | Y Fujii, H Toyooka, H Tanaka |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 81
Issue 3
Pg. 390-2
(Sep 1998)
ISSN: 0007-0912 [Print] England |
PMID | 9861127
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Retracted Publication)
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Chemical References |
- Antiemetics
- Serotonin Antagonists
- Granisetron
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Topics |
- Administration, Oral
- Antiemetics
(administration & dosage)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Granisetron
(administration & dosage)
- Humans
- Male
- Postoperative Nausea and Vomiting
(prevention & control)
- Serotonin Antagonists
(administration & dosage)
- Tonsillectomy
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