Cerebral candidiasis in a child 1 year after leukaemia.

Abstract

We describe an unusual case of a late presentation of a fungal brain abscess in a non-neutropenic child 1 year after completing chemotherapy for M5 acute myeloid leukaemia (AML). Biopsy of the mass identified candidal hyphae and the patient was treated with 5 mg/kg of liposomal amphotericin B for 6 weeks. The lesion resolved completely and the child remains well 2 years later. Invasive fungal infection should be included in the differential diagnosis of unexplained symptoms in patients who have previously received intensive chemotherapy.

• Authors: D A Tweddle, J C Graham, G S Shankland, J Kernahan
• Journal: British journal of haematology (Br J Haematol) Vol. 103 Issue 3 Pg. 795-7 (Dec 1998) ISSN: 0007-1048 [Print] England
• PMID: 9858234 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Antineoplastic Agents
• Amphotericin B

Topics

• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Antineoplastic Agents (adverse effects)
• Brain Abscess (etiology)
• Candidiasis (etiology)
• Child, Preschool
• Female
• Humans
• Leukemia, Monocytic, Acute (drug therapy)