Abstract | BACKGROUND: The role of spinal nitric oxide (NO) in neuropathic pain remains uncertain. Although intrathecal clonidine causes NO release in the spinal cord, the functional role of spinal NO in clonidine-produced analgesia has not been examined. The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine. METHODS: RESULTS: CONCLUSIONS: These results demonstrate that spinal NO neither contributes significantly to maintenance of allodynia nor produces detectable antiallodynic effect in this neuropathic pain model. Furthermore, this study provides functional evidence that spinal NO plays an important role in the antiallodynic effect of intrathecal clonidine in neuropathic pain.
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Authors | H L Pan, S R Chen, J C Eisenach |
Journal | Anesthesiology
(Anesthesiology)
Vol. 89
Issue 6
Pg. 1518-23
(Dec 1998)
ISSN: 0003-3022 [Print] United States |
PMID | 9856728
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Adrenergic alpha-Agonists
- Analgesics
- Enzyme Inhibitors
- Nitric Oxide
- S-Nitroso-N-Acetylpenicillamine
- Nitric Oxide Synthase
- Penicillamine
- Clonidine
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage, pharmacology)
- Analgesics
(pharmacology)
- Animals
- Clonidine
(administration & dosage, pharmacology)
- Enzyme Inhibitors
(pharmacology)
- Injections, Spinal
- Male
- Nitric Oxide
(physiology)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Pain
(etiology, physiopathology, prevention & control)
- Pain Measurement
(drug effects)
- Penicillamine
(analogs & derivatives, pharmacology)
- Peripheral Nervous System Diseases
(complications)
- Rats
- Rats, Sprague-Dawley
- S-Nitroso-N-Acetylpenicillamine
- Spinal Cord
(physiology)
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