Abstract | BACKGROUND: METHODS: RESULTS: Compared with baseline values in the supine position (T1), inhalation of 10 ppm nitric oxide for 1 h (T2) decreased the mean pulmonary artery pressure from 33+/-9 mmHg to 28+/-6 mmHg (P < 0.05; T2 vs. T1) and increased the ratio of the partial pressure of oxygen in arterial blood (PaO2) to inspired oxygen concentration (FiO2) from 115 (median first quartile [Q1] 97, median third quartile [Q3] 137) to 148 (Q1 132, Q3 196) (P < 0.05; T2 vs. T1). Cessation of nitric oxide brought the values back to baseline (T3). Two hours of prone positioning (T4) significantly increased the PaO2:FiO2 ratio (T4 vs. T3). However, after an additional hour of nitric oxide inhalation in the prone position (T5), a significant decrease of the venous admixture (from 33+/-6% to 25+/-6%; P < 0.05) and an increase of the PaO2:FiO2 ratio (from 165 [Q1 129, Q3 216] to 199 [Q1 178, Q3 316] [P < 0.05; T5 vs. T4]) were observed. CONCLUSIONS:
|
Authors | P Germann, G Pöschl, C Leitner, G Urak, R Ullrich, B Faryniak, G Röder, A Kaider, R Sladen |
Journal | Anesthesiology
(Anesthesiology)
Vol. 89
Issue 6
Pg. 1401-6
(Dec 1998)
ISSN: 0003-3022 [Print] United States |
PMID | 9856714
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Aged
- Blood Gas Analysis
- Female
- Humans
- Male
- Middle Aged
- Nitric Oxide
(therapeutic use)
- Oxygen
(blood)
- Oxygen Inhalation Therapy
- Prone Position
(physiology)
- Prospective Studies
- Pulmonary Circulation
(drug effects)
- Respiratory Distress Syndrome
(diagnostic imaging, physiopathology, prevention & control)
- Respiratory Function Tests
- Supine Position
(physiology)
- Tomography, X-Ray Computed
|