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Ovarian dysgerminoma showing high serum levels and positive immunostaining of placental alkaline phosphatase and neuron-specific enolase associated with elevation of serum prolactin level.

Abstract
We report a 35-year-old Japanese female patient with ovarian dysgerminoma showing elevated serum levels of placental alkaline phosphatase (PLAP), neuron-specific enolase (NSE) and prolactin (PRL). All elevated tumor markers improved dramatically after the removal of the tumor. Immunohistochemically examined, the tumor was stained positive for PLAP and NSE and negative for PRL. Our present case is the first report of dysgerminoma showing positive immunostaining for PLAP and NSE, and the association of high serum level of PRL followed by decrease accompanied by the tumor debulking.
AuthorsM Yoshida, M Koshiyama, M Konishi, H Fujii, H Nanno, M Hayashi, K Kanehira, M Matsuki, K Tauchi
JournalEuropean journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 81 Issue 1 Pg. 123-8 (Oct 1998) ISSN: 0301-2115 [Print] Ireland
PMID9846727 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Prolactin
  • Alkaline Phosphatase
  • Phosphopyruvate Hydratase
Topics
  • Adult
  • Alkaline Phosphatase (analysis, blood)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biomarkers, Tumor
  • Dysgerminoma (metabolism, pathology, surgery)
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Ovarian Neoplasms (metabolism, pathology, surgery)
  • Phosphopyruvate Hydratase (analysis, blood)
  • Placenta (enzymology)
  • Prolactin (analysis, blood)

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