Abstract |
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. To test this hypothesis, we observed the effect of SC-19220 on the fever produced by injection of recombinant human IL-1beta (rhIL-1beta) into the lateral cerebroventricle (LCV) in conscious rats. Administration of SC-19220 (100 microgram) into the LCV 15 min before LCV injection of rhIL-1beta (4 ng) suppressed an initial rise in colonic temperature for 30 min, producing a fever with a longer latency to onset and a longer time to peak elevation. SC-19220, given 60 min after the central administration of rhIL-1beta, also suppressed the rhIL-1beta-induced fever 15-60 min after its injection. These findings suggest that the central IL-1beta-induced fever in rats is mediated, at least partly, by activation of EP1 receptors by PGE2.
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Authors | K Oka, T Oka, T Hori |
Journal | The American journal of physiology
(Am J Physiol)
Vol. 275
Issue 6
Pg. R1762-5
(12 1998)
ISSN: 0002-9513 [Print] United States |
PMID | 9843865
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-1
- Prostaglandin Antagonists
- Receptors, Prostaglandin E
- Recombinant Proteins
- Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
- Dimethyl Sulfoxide
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Topics |
- Animals
- Body Temperature
(drug effects)
- Brain
(physiology)
- Colon
(physiopathology)
- Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
(pharmacology)
- Dimethyl Sulfoxide
(administration & dosage, pharmacology)
- Fever
(chemically induced, prevention & control)
- Humans
- Injections, Intraventricular
- Interleukin-1
(administration & dosage, pharmacology)
- Male
- Prostaglandin Antagonists
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Prostaglandin E
(antagonists & inhibitors)
- Recombinant Proteins
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