Abstract | OBJECTIVE: METHOD: Eighty-five outpatients with a DSM-IV diagnosis of binge-eating disorder were randomly assigned to receive either fluvoxamine (N=42) or placebo (N=43) in a 9-week, parallel-group, double-blind, flexible dose (50-300 mg) study at three centers. The primary outcome measures were frequency of binge eating, expressed as log ([binges/week]+1), and Clinical Global Impression (CGI) scale ratings. Secondary measures included the level of response (based on the percentage change in frequency of binges), body mass index, and Hamilton Rating Scale for Depression score. Except for the level of response, the outcome measures were analyzed by random regression methods; the treatment-by-time interaction was the measure of treatment effect. RESULTS: Compared with placebo, fluvoxamine was associated with a significantly greater rate of reduction in the frequency of binges, rate of reduction in CGI severity scores, rate of increase in CGI improvement scores, level of response for patients who completed the 9-week study, and rate of reduction in body mass index. There was no significant difference between placebo and fluvoxamine groups in the rate of decrease in Hamilton depression scale scores. A significantly greater proportion of patients receiving fluvoxamine than those receiving placebo discontinued treatment because of an adverse medical event. CONCLUSIONS:
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Authors | J I Hudson, S L McElroy, N C Raymond, S Crow, P E Keck Jr, W P Carter, J E Mitchell, S M Strakowski, H G Pope Jr, B S Coleman, J M Jonas |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 155
Issue 12
Pg. 1756-62
(Dec 1998)
ISSN: 0002-953X [Print] United States |
PMID | 9842788
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bulimia
(drug therapy, psychology)
- Double-Blind Method
- Female
- Fluvoxamine
(therapeutic use)
- Humans
- Male
- Middle Aged
- Placebos
- Treatment Outcome
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