Forty-five year's experience of the treatment of choriocarcinoma and invasive mole.

Abstract

Our work was begun in 1949. through many yera's effort, several chemicals (such as 6 MP, 5 FU and others) were found to be effective for the treatment of choriocarcinoma (C.C.) and invasive mole (I.M.). From 1959 through 1985, 1500 patients were consecutively treated. The mortality rate of CC was reduced from > 90% to < 20%. No more death occurred in IM. All Survivors followed up for 10-38 years showed no evidence of residual disease. 80% of the young patients treated with chemotherapy alone conceived after recovery. The pregnancy outcome showed no deviation from that of the general population. All children are growing up normally many married and gave birth to normal third generations. The results indicated that chemotherapy with 5 FU achieves not only a complete remission, but also a cure, even with wide-spread metastases. The results of choriocarcinoma and invasive mole treated with mainly 5 FU were reported. The clinical experience in the management of metastases at different sites were also summarized.

• Authors: H Z Song, X Y Yang, Y Xiang
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 60 Suppl 1 Pg. S77-83 (Apr 1998) ISSN: 0020-7292 [Print] United States
• PMID: 9833619 (Publication Type: Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Fluorouracil

Topics

• Antimetabolites, Antineoplastic (therapeutic use)
• Brain Neoplasms (secondary)
• Choriocarcinoma (drug therapy, secondary)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Hydatidiform Mole, Invasive (drug therapy, secondary)
• Lung Neoplasms (secondary)
• Pregnancy
• Retrospective Studies
• Treatment Outcome
• Uterine Neoplasms (drug therapy, pathology)