p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.

Abstract

The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior adrenodemedullation abolished the hyperglycemia elicited by p-chloroamphetamine. p-Chloroamphetamine-induced hyperglycemia was prevented by methysergide, which blocks the 5-HT1 and 5-HT2 receptor, the 5-HT1A/1B/2C receptor antagonist, (-)-propranolol, the selective 5-HT1A receptor antagonist, 4-(2'-methoxyphenyl-1-[2'-n-2"pyridinyl)-p-iodobenzamido]-ethyl-pi perazine (p-MPPI), the 5-HT2A/2B/2C receptor antagonists, ritanserin and 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6A,7 ,8,9,10,10A-octahydro-indolo[4,3-FG]quinolone maleate(LY 53857). However, the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, the 5-HT4 receptor antagonist, 2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester (SDZ 205-557), and the 5-HT2A receptor antagonist, ketanserin, did not affect the p-chloroamphetamine-induced hyperglycemia. These results suggest that p-chloroamphetamine-induced hyperglycemia is elicited by an enhanced 5-HT release and facilitated adrenaline release. Moreover, our results indicate that p-chloroamphetamine-induced hyperglycemia is mediated by 5-HT1A and 5-HT2B/2C receptors.

• Authors: J Yamada, Y Sugimoto, T Yoshikawa
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 359 Issue 2-3 Pg. 185-90 (Oct 23 1998) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9832390 (Publication Type: Journal Article)

Chemical References

• Aminopyridines
• Blood Glucose
• Ergolines
• Indoles
• Piperazines
• Receptor, Serotonin, 5-HT2B
• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• Serotonin Agents
• Serotonin Antagonists
• para-Aminobenzoates
• 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester
• Ritanserin
• 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine
• Serotonin
• p-Chloroamphetamine
• Tropisetron
• Ketanserin
• Propranolol
• LY 53857
• Fenclonine
• 4-Aminobenzoic Acid
• Methysergide

Topics

• 4-Aminobenzoic Acid (pharmacology)
• Adrenal Medulla (physiology)
• Adrenalectomy
• Aminopyridines (pharmacology)
• Animals
• Blood Glucose (drug effects, metabolism)
• Dose-Response Relationship, Drug
• Ergolines (pharmacology)
• Fenclonine (pharmacology)
• Hyperglycemia (chemically induced, physiopathology, prevention & control)
• Indoles (pharmacology)
• Ketanserin (pharmacology)
• Male
• Methysergide (pharmacology)
• Piperazines (pharmacology)
• Propranolol (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptor, Serotonin, 5-HT2B
• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin (physiology)
• Receptors, Serotonin, 5-HT1
• Ritanserin (pharmacology)
• Serotonin (metabolism)
• Serotonin Agents (pharmacology)
• Serotonin Antagonists (pharmacology, therapeutic use)
• Tropisetron
• p-Chloroamphetamine (pharmacology)
• para-Aminobenzoates