Abstract |
The purpose of this study was to compare striatal D2 dopamine receptor occupancy of various typical neuroleptics and clozapine in relation to the occurrence of extrapyramidal side effects (EPS). Forty-four inpatients with schizophrenia, including 12 patients with schizodominant schizoaffective disorder, were evaluated using 123I-iodobenzamide ( IBZM) and single photon emission computed tomography. Striatal D2 dopamine receptor occupancy was estimated by use of a striatal/frontal cortex ratio (ST/FC) of IBZM binding. Fourteen patients were neuroleptic-free and served as controls. Six patients were treated with clozapine and 24 patients were treated with various typical neuroleptics. ST/FC ratios in patients taking typical neuroleptics were significantly lower than those who were neuroleptic free or treated with clozapine. Patients with EPS had lower ST/FC ratios than those without EPS. A significant linear relationship between ST/FC ratios and severity of EPS estimated by the Simpson-Angus-Scale was established (r=-0.51, p=0.041).
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Authors | K Broich, F Grünwald, S Kasper, E Klemm, H J Biersack, H J Möller |
Journal | Pharmacopsychiatry
(Pharmacopsychiatry)
Vol. 31
Issue 5
Pg. 159-62
(Sep 1998)
ISSN: 0176-3679 [Print] Germany |
PMID | 9832346
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Benzamides
- Pyrrolidines
- Radiopharmaceuticals
- Receptors, Dopamine D2
- 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
- Clozapine
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Topics |
- Adult
- Antipsychotic Agents
(adverse effects, metabolism)
- Basal Ganglia Diseases
(chemically induced, diagnostic imaging)
- Benzamides
- Clozapine
(adverse effects, metabolism)
- Dose-Response Relationship, Drug
- Female
- Frontal Lobe
(diagnostic imaging, metabolism)
- Humans
- Male
- Neostriatum
(diagnostic imaging, metabolism)
- Pyrrolidines
- Radiopharmaceuticals
- Receptors, Dopamine D2
(drug effects, metabolism)
- Schizophrenia
(drug therapy, metabolism)
- Tomography, Emission-Computed, Single-Photon
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