Abstract | OBJECTIVE: Because eosinophils likely play important roles in the pathophysiology of allergic diseases, specific inhibitors of eosinophils may be desirable to treat such diseases. To evaluate the capacity of a novel compound, sulochrin, as an inhibitor of eosinophilic inflammation, we examined the effects of this compound on various effector functions of eosinophils. MATERIALS AND METHODS: RESULTS:
Sulochrin inhibited EDN release by eosinophils stimulated with sIgA-beads. IgG-beads and PAF in a concentration-dependent manner; IC50 values were 0.75 microM, 0.30 microM and 0.03 microM. Eosinophil O2- production, LTC4 release, and IL-8 production were also inhibited by sulochrin. Furthermore, PAF-induced chemotaxis of human eosinophils and LTB4-induced chemotaxis of guinea pig eosinophils were abolished by 1 microM of sulochrin. Finally, sulochrin potently inhibited LTB4-induced infiltration of eosinophils into the skin of guinea-pig in vivo. CONCLUSIONS: These results suggest that sulochrin is a potent inhibitor of various effector functions of eosinophils. Sulochrin and its derivatives may be useful in the development of therapeutic approaches for patients with allergic diseases.
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Authors | H Ohashi, Y Motegi, H Kita, G J Gleich, T Miura, M Ishikawa, H Kawai, H Fukamachi |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 47
Issue 10
Pg. 409-15
(Oct 1998)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 9831326
(Publication Type: Journal Article)
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Chemical References |
- Anti-Allergic Agents
- Benzoates
- Immunoglobulin A
- Immunoglobulin G
- Interleukin-8
- Platelet Activating Factor
- Superoxides
- Leukotriene B4
- Leukotriene C4
- sulochrin
- Sepharose
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Topics |
- Animals
- Anti-Allergic Agents
(pharmacology)
- Benzoates
(pharmacology)
- Cell Degranulation
(drug effects)
- Chemotaxis, Leukocyte
(drug effects)
- Eosinophils
(drug effects, immunology, physiology)
- Guinea Pigs
- Humans
- Immunoglobulin A
(immunology)
- Immunoglobulin G
(immunology)
- Interleukin-8
(biosynthesis)
- Leukotriene B4
(pharmacology)
- Leukotriene C4
(metabolism)
- Platelet Activating Factor
(pharmacology)
- Sepharose
- Superoxides
(metabolism)
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