Abstract | OBJECTIVE AND DESIGN: MATERIAL: In vitro, lysate of rat basophilic leukemia cells, the microsome fraction of sheep seminal vesicles, human polymorphonuclear leukocytes, human synovial cells, and human monocytes. Ex vivo and in vivo, male Balb/c mice or SD rats. TREATMENT: METHODS: RESULTS: CONCLUSIONS: The anti-inflammatory characteristics of ER-34122 are considered to be superior to those of COX inhibitors such as indomethacin, because in addition to its inhibitory activity on the COX pathway, ER-34122 inhibits LOX products generation, as revealed by the inhibition of edema formation or polymorphonuclear leukocyte infiltration in the arachidonic acid-induced ear inflammation model.
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Authors | T Horizoe, N Nagakura, K Chiba, H Shirota, M Shinoda, N Kobayashi, H Numata, Y Okamoto, S Kobayashi |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 47
Issue 10
Pg. 375-83
(Oct 1998)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 9831321
(Publication Type: Journal Article)
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Chemical References |
- 5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide
- Anti-Inflammatory Agents, Non-Steroidal
- Benzamides
- Cyclooxygenase Inhibitors
- Lipoxygenase Inhibitors
- Pyrazoles
- Leukotriene B4
- Arachidonic Acid
- Leukotriene C4
- Carrageenan
- Peroxidase
- Dinoprostone
- Indomethacin
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Arachidonic Acid
- Benzamides
(therapeutic use)
- Carrageenan
- Cyclooxygenase Inhibitors
(therapeutic use)
- Dinoprostone
(biosynthesis)
- Edema
(chemically induced, drug therapy)
- Humans
- Indomethacin
(therapeutic use)
- Leukotriene B4
(biosynthesis)
- Leukotriene C4
(biosynthesis)
- Lipoxygenase Inhibitors
(therapeutic use)
- Male
- Mice
- Mice, Inbred BALB C
- Otitis
(chemically induced, drug therapy)
- Peroxidase
(metabolism)
- Pyrazoles
(therapeutic use)
- Rats
- Sheep
- Tumor Cells, Cultured
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