Abstract | OBJECTIVE: STUDY DESIGN: Thirty patients, each with a chief complaint of mouth burning without oral mucosal lesions, were entered into the study. All patients underwent routine blood screens. Identified abnormalities were corrected, when possible, before clonazepam was prescribed. The starting dose was 0.25 mg daily, with an increase in dose of 0.25 mg on a weekly basis if symptoms continued. RESULTS: The subject population consisted of 29 women and 1 man. All subjects had been symptomatic (average premorbid burning intensity, 7.0 +/- 1.9 on 10-point scale) for 1 month to 12 years (mean, 3.9 +/- 3.4 years; median, 2.75 years), and 16% had had burning for more than 2 years. Three groups of patients were identified: those who experienced partial to complete relief with clonazepam and who were using the medication at the last follow-up (group 1; 43%); those who found the clonazepam helpful but withdrew from the medication because of side effects--usually drowsiness (group 2; 27%); and those who did not benefit from clonazepam (group 3; 30%). Among the 3 groups, age was found to be significantly lower for group 1 than for group 2 but not significantly lower for group 1 than for group 3. Although the difference did not reach significance, the mean dose of clonazepam appeared lower for group 1 patients than for the other 2 patient groups. The number of patients with burning for less than 2 years was larger in group 1 than in the other groups. CONCLUSIONS:
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Authors | M Grushka, J Epstein, A Mott |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 86
Issue 5
Pg. 557-61
(Nov 1998)
ISSN: 1079-2104 [Print] United States |
PMID | 9830647
(Publication Type: Journal Article)
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Chemical References |
- GABA Modulators
- Clonazepam
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Topics |
- Aged
- Aged, 80 and over
- Analysis of Variance
- Burning Mouth Syndrome
(drug therapy)
- Chronic Disease
- Clonazepam
(administration & dosage, therapeutic use)
- Female
- GABA Modulators
(administration & dosage, therapeutic use)
- Humans
- Male
- Middle Aged
- Pilot Projects
- Statistics, Nonparametric
- Treatment Outcome
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